If you’re looking to learn more about edibles’ function in our bodies, you’ve come to the right place. Here’s a look at how cannabinoids are absorbed and why they’re more potent in the liver than inhaled. It’s essential to remember that the dosage of edibles is different than smoking and that a marijuana edible should be consumed in moderation.
Cannabinoids dissolve in fats to be absorbed in the intestines.
Cannabinoids have a very natural home in your body. They dissolve in fats and oils and are absorbed by the intestines. Eating them increases their bioavailability, as they can quickly pass through your digestive system.
Fats are also crucial for your immune system. Eating them can help improve the bioavailability of cannabinoids, which may help keep you healthy.
There are numerous benefits to eating foods rich in fats, including lower symptoms of depression and anxiety. In addition, they have been shown to inhibit drug efflux transporters and increase the delta 9 distillate of cannabinoids.
Fatty food also increases the bioavailability of cannabinoids, so they are more likely to reach their full potential. This is especially true of cannabis compounds. These are lipophilic chemicals requiring fats to dissolve in your body.
Most cannabis edibles utilize dietary lipids to boost their potency. For example, coconut oil is a popular carrier of cannabinoids, as it contains a high concentration of medium-chain fatty acids. However, a study found that cocoa butter was the best vehicle for absorbing cannabis compounds.
Regarding cannabinoids, the oil-to-plant material route is also an effective way to increase their bioavailability. So adding sunflower oil to your pot brownies could also boost the effects of cannabinoids.
THC is more potent in the liver than THC inhaled
The pharmacokinetics of THC inhaled and injected differ significantly. Injections deliver a single bolus, while inhalation provides an ongoing infusion. Both routes of administration have peak plasma THC concentrations within a few hours. However, plasma THC levels are lower after inhalation, likely due to the enterohepatic pathway.
The liver is a primary site of THC metabolism. Injections yield higher plasma concentrations of 11-OH-THC, which is a psychoactive metabolite. However, inhalation produces higher THC levels in the brain. This is likely due to the faster delivery of inhaled compounds through highly perfused tissues.
THC-COOH concentrations in the brain peak at approximately 90 minutes after injection. This is a relatively short period, and previous literature has shown that rises in the brain occur earlier than 30 minutes after inhalation.
Delta-9-THC is metabolized in the liver to 11-OH-THC. Both metabolites are potent and exhibit substantial psychoactive effects. But 11-OH-THC may be more effective than delta-9-THC. A study in rodents published in 2020 showed that 11-hydroxy-THC is more potent than delta-9-THC.
Interestingly, inhalation of THC failed to elicit cross-sensitization to morphine. Moreover, the onset of hypothermia was faster after inhalation, and the plasma THC concentration was higher after inhalation than after injection.
Nevertheless, ingested cannabinoids are more bioavailable than inhaled cannabinoids. Several factors contribute to this. These include relative increases in body fat and liver clearance.
Eating too much
There are a few things to do if you are the type that consumes edibles at a decent rate. If you have yet to try this illuminating beverage in the wild, you might be surprised to learn that you are not alone. Some people have been known to have a difficult time swallowing the stuff. Fortunately, most legal states have regulations to ensure your tummy does not turn into a buffet. A good rule of thumb is to keep the lid closed if possible and drink it up in the privacy of your own home. Keeping yourself occupied may be the only way to make it happen. Having friends or family nearby is a good idea if you want company. Having a few high-quality drinks in tow will make your experience much more pleasant.
Overeating the good stuff will also spell trouble. Luckily, most manufacturers have come up with a well-vetted recipe for success. Using a quality oral rinse as part of your dental health regimen will go a long way toward keeping your mouth from lining up the door.
The dosage of edibles is different from smoking.
If you’re a new consumer, you’ll want to understand the dosing of edibles. While there’s no “standard” dosage, you’ll find that the amount varies from one person to another.
First-time users should start with a small dose. This will give them a clearer understanding of what effects they can expect. Then, as they become more experienced, they might increase the dosage.
Generally, edibles can take up to three hours to kick in. During this time, they’re digested, broken down, and absorbed. The effects vary depending on the user, their body, and the strain they’re ingesting. Taking the wrong dosage could lead to an uncomfortable experience.
Some edibles contain higher amounts of THC than others. Those with the highest levels typically have a more intoxicating effect. However, they can also cause unwanted side effects, such as paranoia.
Some people may also experience anxiety or nausea and an increased heart rate. When this occurs, it’s essential to consume plenty of water and orange juice.
Most dispensaries will list the dosage of each product. For example, gummies may have a dose of 5 milligrams. Other products, such as chocolate bars, can have as much as 20 milligrams. These dosing recommendations are important because if you take too much of any cannabinoid, you may suffer from unwanted side effects.